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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histologicalthe translational value of this well-annotated PDX panel in the development of co-clinical trials for patientstratification and treatment optimization in the near future.

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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A methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection

Frontiers in Energy 2023, Volume 17, Issue 5,   Pages 678-691 doi: 10.1007/s11708-022-0859-z

Abstract: This paper aims to improve the engine performance of the GCI mode by regulating concentration stratification

Keywords： gasoline compression ignition     injection strategy     fuel stratification     high efficiency     high load    

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Comparison of prechilling stratification and sulfuric acid scarification on seed germination of

Nan WANG, Jing GAO, Suiqi ZHANG, Feng YAN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 2,   Pages 220-227 doi: 10.15302/J-FASE-2017146

Abstract: To determine if prechilling stratification (PCS) and sulfuric acid scarification (SAS) can optimize establishment

Keywords： base water potential     data analysis method     embryo growth     germination    

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Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 957-968 doi: 10.1007/s11684-021-0910-1

Abstract: A PPGF–AKI–HAP risk stratification system was established with a mortality risk score of 1×PPGF+1×AKI

Keywords： skin and soft tissue infections     hematopoietic stem cell transplantation     risk stratification system    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide     APL     rhabdomyolysis    

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Chaotic behavior of LNG after stratification in main stream region of storage tank

WANG Jingjing, MA Xiaoqian

Frontiers in Energy 2008, Volume 2, Issue 4,   Pages 514-518 doi: 10.1007/s11708-008-0076-4

Abstract: A study of the chaotic behavior of liquefied natural gas (LNG) after stratification in the main stream

Keywords： Runge-Kutta     non-linear     corresponding     temperature     addition    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: To identify the potential pathogenic mutations in a Chinese patient with CF, we conducted Sanger sequencingon the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR andThe patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cisOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10 was altered in 18 types of cancers and was associated with the clinical outcomes of 11 cancer types. In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients. In 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney tissues. Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse prognosis. Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophages phagocytosing KIRC cells. In addition, luciferase activity assays suggested that Siglec10 was a potential target of the transcription factors c-FOS and GATA1, which were identified by data mining. These results demonstrate that Siglec10 may have important oncogenic functions in KIRC, and represents a novel target for the development of immunotherapies.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 334-339 doi: 10.1007/s11684-017-0539-2

Abstract: Our patient is a male and 5 years and 3 months of age.

Keywords： PVS     stubborn disease     Xingnao Kaiqiao     Angong Niuhuang Wan     TCM     acupuncture    

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Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 259-263 doi: 10.1007/s11684-014-0321-7

Abstract:

Although significant breakthroughs have been achieved in tuberculosis management, we still encounter numerous difficulties in diagnosis and treatment of the disease. Additionally, a new challenge, multidrug-resistant tuberculosis (MDR-TB) with unspecific clinical presentation, often results in delayed diagnosis. In this paper, we reported a case of disseminated tuberculosis with rare presentation of ventricular fibrillation, which proved resistant to both isoniazid and rifampicin. A review of literature showed that ventricular fibrillation or tachycardia in tuberculosis patients with pericarditis or myocarditis has been sporadically reported in the past, but none has been conducted involving patients with MDR-TB infections.

Keywords： tuberculosis     MDR-TB     ventricular tachycardia    

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Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 250-253 doi: 10.1007/s11684-014-0333-3

Abstract:

The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively.The patient has suffered from hepatitis B for 30 years.The patient also presented hepatocellular carcinoma.The patient recovered uneventfully and was discharged after surgery.

Keywords： acute-on-chronic liver failure     submassive necrosis     viral hepatitis B     esophageal variceal bleeding     liver transplantation    

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Reverse engineering in the construction of numerical simulation oriented patient-specific model of stented

Xianlong MENG, Wenyu FU, Yun ZHANG, Aike QIAO,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3,   Pages 328-335 doi: 10.1007/s11465-010-0026-9

Abstract: Patient-specific models are widely used in hemodynamic simulations.is necessary to investigate the approaches to the reconstruction of a numerical simulation-oriented patient-specific

Keywords： reverse engineering     aortic arch aneurysm     surface model     meshing     finite element model    

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Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 191-194 doi: 10.1007/s11684-008-0036-8

Abstract: A 35-year-old male patient presented with a 4-year history of recurrent bullae on his trunk and extremitiesThe patient had shown resistance to conventional therapy with glucocorticoid and immunosuppressive agentsThe patient was in complete drug-free remission with no evidence of residual clinical or serologicalThe patient’s response suggests that autologous peripheral hematopoietic stem cell transplantation may

Keywords： serological activity     leukapheresis     peripheral hematopoietic     cyclophosphamide     resistance    

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Catheterization via direct cannulation of superior vena cava for a hemodialysis patient with an original

Li Zhou, Lin Chen, Yang Yu, Tianlei Cui, Xiao Li, Ping Fu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 445-448 doi: 10.1007/s11684-017-0520-0

Abstract: this study, we reported a case of a direct catheterization in the superior vena cava of a hemodialysis patientis one of the few reports regarding direct catheterization of CUFF via the superior vena cava of a patientbelieve that our study can provide a new alternative for inserting central venous catheter for such patient

Keywords： superior vena cava     intervention     vascular access exhaustion     catheterization     tunneled cuffed hemodialysis catheter    

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Title Author Date Type Operation

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Journal Article

A methodology for regulating fuel stratification and improving fuel economy of GCI mode via double main-injection

Journal Article

Comparison of prechilling stratification and sulfuric acid scarification on seed germination of

Nan WANG, Jing GAO, Suiqi ZHANG, Feng YAN

Journal Article

Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell

Journal Article

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Journal Article

Chaotic behavior of LNG after stratification in main stream region of storage tank

WANG Jingjing, MA Xiaoqian

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Journal Article

Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Journal Article

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Journal Article

Reverse engineering in the construction of numerical simulation oriented patient-specific model of stented

Xianlong MENG, Wenyu FU, Yun ZHANG, Aike QIAO,

Journal Article

Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

SUN Ledong, SUN Jing, ZENG Kang, MENG Fanyi, DIAO Youtao, XU Dan, HUANG Liang, ZHAO Jie, Liu Qifa

Journal Article

Catheterization via direct cannulation of superior vena cava for a hemodialysis patient with an original

Li Zhou, Lin Chen, Yang Yu, Tianlei Cui, Xiao Li, Ping Fu

Journal Article